Tuberculosis and human T-cell lymphotropic virus type 1 infection.
نویسنده
چکیده
SIRIn a recent review of the infectious complications of human T-cell lymphotropic virus type I (HTLV-I) infection, Marsh [1] suggested that those individuals infected with HTLV-I may be at increased risk of tuberculosis. This risk may be due to reduced delayed-type hypersensitivity to PPD in asymptomatic patients infected with HTLV-l. Up to 14% of the population in Papua New Guinea are infected with HTLV-I [2] and this Melanesian virus is genetically distinct from HTLV-1 isolated elsewhere [3]. Tuberculosis is the commonest reason for hospital admissions of adults in Papua New Guinea, and the national incidence of active disease is estimated to be 0.9 per 1,000 population per annum [4]. Tuberculosis complicates symptomatic HIV infection in 69% of patients in Papua New Guinea (author's unpublished data), but as yet, rates of HIV infections are low among patients receiving treatment at tuberculosis clinics. Despite these findings, investigators who recently studied a heterogeneous population in Papua New Guinea with use of a particle agglutination test [5] failed to detect any patients with HTLV-I infection among 102 HIV-negative patients with laboratory-proven tuberculosis (86 cases of pulmonary infection and 16 cases of extrapulmonary infection). Although the possibility of an associa~ion between tuberculosis and HTLV-1 infection is compelling, it IS not yet clinically obvious in Papua New Guinea, where both infections are endemic. Other established clinical associations with HTLV-1 infection in Papua New Guinea remain elusive. The relatively short life expectancy of Papua New Guinea residents coupled with the long latent period of disease related to HTLV-1 that has been reported elsewhere may make such associations -in particular an association with tuberculosis, which is primarily a disease of children and young to middle-aged adults-difficult to identify. Detection of HTLV-l-related disease in Papua New Guinea may be improved if specific ethnic groups with high seroprevalence rates, such as the highland fringe-dwelling Hagahai [2], are targeted.
منابع مشابه
Frequency of Human T-Cell Lymphotropic Virus (HTLV) Type 1 and 2 Infection in HIV Infected Patients
Background and Objectives: Human T-cell lymphotropic viruses (HTLV) type 1 and 2 are retroviruses that share the same routes of transmission as human immunodeficiency virus (HIV). As a consequence of epidemiologic similarities, HIV and HTLV-1/2 co-infection is frequent. Due to the limited data, this study assessed the seroprevalence of HTLV-1/2 infections in HIV infected patients in Tehran, Ira...
متن کاملEvaluating the Frequency of Human T-Lymphotropic Virus Type 1 Infection in Iranian Population
Background: Human T-cell lymphotropic viruses 1 (HTLV1) is endemic in specific regions. We aimed to determine the prevalence of HTLV I infection among blood donors in southeast Iran. Methods: This cross-sectional study was conducted between April 2005 and March 2015. Sera were collected from blood donors and were tested for the presence of HTLV1 specific antibody using ELISA. Reactive sample...
متن کاملEvaluating the frequency of HTLV-Ι/Π infection among blood donors, major thalassemic patients and individuals infected with hepatitis B and C viruses in Isfahan, Iran
Background: The human T-cell lymphotropic virus type I is the first retrovirus idenfied in humans. The virus has been associated with adult T-cell leukemia/lymphoma, human T-lymphotropic virus type I, myelopathy/tropical spasc paraparesis, uveis, arthris, pulmonary lymphocyc alveolis, keratoconjuncvis sicca, and infecous dermas. Human T-lymphotropic virus type Iis endemic in Japan...
متن کاملHuman T Lymphotropic Virus Type I (HTLV-I) Oncogenesis: Molecular Aspects of Virus and Host Interactions in Pathogenesis of Adult T cell Leukemia/Lymphoma (ATL)
The study of tumor viruses paves the way for understanding the mechanisms of virus pathogenesis, including those involved in establishing infection and dissemination in the host tumor affecting immune-compromised patients. The processes ranging from viral infection to progressing malignancy are slow and usually insufficient for establishment of transformed cells that develop cancer in only ...
متن کاملThe Enigma of Human T-Cell Leukemia Virus Type-1 (HTLV-1) Infection in Iran
Human T-cell lymphotropic virus type-I (HTLV-I) was the first human retrovirus associated with malignancy. The prevalence of HTLV-I infection varies significantly in different regions of the world. In this study, the prevalence of HTLV-I infection among ethnic Jews living in Shiraz, South of Iran, was investigated. 286 blood samples were obtained. HTLV-1 antibody assay on serum samples was d...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
دوره 24 5 شماره
صفحات -
تاریخ انتشار 1997